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KMID : 0605720110170020239
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Journal of the Korean Society of Biological Therapies in Psychiatry
2011 Volume.17 No. 2 p.239 ~ p.249
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Association Study of Corticotropine-Releasing Hormone Recepter 1(CRHR1) Gene Polymorphism in Korean Alcohol-Dependent Patients
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Kim Cheol-Min
Kim Ji-Hoon
Kim Sung-Gon
Kim Hyeun-Kyeung
Kim Mi-Kyung
Ryu Jung-Hyun
Min Eun-Jeong
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Abstract
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Objectives: There were several preceding studies investigating the association between alcohol dependence and corticotropine releasing hormone receptor1(CRHR1) gene SNPs that play an important role in response to stress. The frequencies of CRHR1 genotypes and alleles were compared between alcohol-dependent patients and normal control subjects.
Methods: The subjects were 268 alcohol-dependent patients(218 males, 50 females) and 137 normal controls(78 male, 59 female). CRHR1 gene SNPs were investigated according to the SNP database and the results from previous studies, and their genotypes were analyzed by polymerase chain reaction(PCR) and restriction fragment length polymorphism(RFLP).
Results: Seven CRHR1 gene SNPs(rs242938, rs404623, rs28364027, rs16940686, rs937, rs878886, rs878887) were found in Korean subjects. The frequency of rs28364027 A allele was significantly higher in alcohol-dependent patients than normal controls in both genders. In alcohol-dependent patients, the frequencies of AA genotype and A allele of rs28364027, and of CC genotype and C allele of rs878886 were higher in female than male.
Conclusion: These results suggest that CRHR1 gene SNP is one of the important genetic factors in the etiology of alcohol dependence. And also it is supposed that the different frequency of SNP genotype could explain stress-related gender difference in the genetic etiology of alcohol dependence.
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KEYWORD
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CRHR1 gene SNP, Genotype frequency, Allele frequency, Alcohol dependence
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